مقاله‌ای با عنوان «The Evaluation of Intra-Articular Injection of Bevacizumab on the Prevention of Physeal Bar Formation in Type 4 Salter Harris Model in Rats: A Pilot Study» در تاریخ سپتامبر 2021 با وابستگی مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی به چاپ رسیده است.

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Title: The Evaluation of Intra-Articular Injection of Bevacizumab on the Prevention of Physeal Bar Formation in Type 4 Salter Harris Model in Rats: A Pilot Study

Authors: Zeinab Imani, Nesa Milan, Hossein Nematian, Leila Aghaghazvini, Niayesh Mohebbi, Mojtaba Sedaghat, Mohammad Bagher Ahadpour Sefidan, Alireza Mirbagheri, Mohammad Hossein Nabian

DOI: 10.18502/jost.v7i3.8103

Abstract:

Background: This study was designed to achieve a new method as a preventive treatment for complications of growth plate fractures. In this study, we investigate the effect of intra-articular injection of anti-vascular endothelial growth factor (anti-VEGF) antibody bevacizumab on the repair process of articular cartilage in a type 4 Salter Harris injury model.

Methods: A Salter Harris injury was created on the proximal tibial growth plate of 14 rats by a 1.8 mm drill. The rats were randomly classified into two groups: group LD, administration of high-dose intra-articular injection of bevacizumab (250 μg), and group HD, administration of low-dose intra-articular injection of bevacizumab (50 μg) after injury. The rats were killed 2 months postoperatively and their tibia underwent micro-computed tomography (CT) analysis, histological assessment, and measurement of tibial bone length. Results: Bony bar formation was observed in 71% of the samples in the high-dose group and in 100% of the low-dose group. Relative increase in physeal cartilage thickness (P = 0.007) and decrease in bony bar formation (P = 0.029) were observed significantly in the high dose group. There was no significant difference in tibia length between the two groups (P = 0.150).

Conclusion: Intra-articular administration of bevacizumab demonstrated positive restorative effects. We suggest this method of treatment due to its potential of improving cartilage repair and capability to be used as a main or adjacent treatment in osteochondral defects.

Keywords: Salter-Harris Fractures; Growth Plate Fracture; Vascular Endothelial Growth Factors; Bevacizumab; Orthopedics.